TP53 Antibody - middle region
Catalog Number:
ASB-ARP97250_P050
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| Article Name: | TP53 Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP97250_P050 |
| Supplier Catalog Number: | ARP97250_P050 |
| Alternative Catalog Number: | ASB-ARP97250_P050-25UL,ASB-ARP97250_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human TP53 |
| Alternative Names: | P53, BCC7, LFS1, BMFS5, TRP53 |
| This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants. |
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Host: Rabbit Target Name: TP53 Sample Tissue: Human HT1080 Whole Cell lysates Antibody Dilution: 1ug/ml |
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25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment. Canonical 43 kDa isoform is identified, and a second isoform of 52 kDa is also present in some samples |
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