The antiserum was produced against synthesized peptide derived from human PPAR-BP around the phosphorylation site of Thr1457.
Alternative Names:
activator-recruited cofactor 205 kDa component,ARC205,CRSP1,CRSP200,DRIP205,DRIP230,Mediator complex subunit 1,mediator of RNA polymerase II transcription subunit 1,p53 regulatory protein RB18A,PBP,peroxisome proliferator-activated receptor-binding protein,PPAR-binding protein,PPARBP,PPARG binding protein,PPARGBP,RB18A,thyroid hormone receptor-associated protein complex 220 kDa component,thyroid hormone receptor-associated protein complex component TRAP220,thyroid receptor interacting protein 2,Thyroid receptor-interacting protein 2,TRAP220,TR-interacting protein 2,TRIP2,TRIP-2,vitamin D receptor-interacting protein 230 kD,vitamin D receptor-interacting protein complex component DRIP205.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
