B220,CD45,CD45 antigen,CD45R,GP180,LCA,L-CA,Leukocyte common antigen,LY5,protein tyrosine phosphatase, receptor type, c polypeptide,receptor-type tyrosine-protein phosphatase C,T200,T200 glycoprotein,T200 leukocyte common antigen.
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
