NBL1 (NP_005371, 21 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Alternative Names:
D1S1733E,DAN,DAN domain family member 1,DAND1,differential screening-selected gene aberrant in neuroblastoma,NB,neuroblastoma 1, DAN family BMP antagonist,neuroblastoma candidate region, suppression of tumorigenicity 1,neuroblastoma suppressor of tumorigenicity 1,NO3.
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
