Recombinant Human N-alpha-acetyltransferase 10 protein (161-235AA)
Conjugation:
Unconjugated
Alternative Names:
ARD1,ARD1 homolog A, N-acetyltransferase,ARD1A,ARD1P,arrest defective protein 1,DXS707,hARD1,MCOPS1,N-acetyltransferase ARD1, human homolog of,N-alpha-acetyltransferase 10,natA catalytic subunit Naa10,NATD,N-terminal acetyltransferase complex ARD1 subunit homolog A,OGDNS,TE2.
Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at Lys-77 which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821).
