ARG2 Antibody
Catalog Number:
ASB-OACA06838
- Images (3)
| Article Name: | ARG2 Antibody |
| Biozol Catalog Number: | ASB-OACA06838 |
| Supplier Catalog Number: | OACA06838 |
| Alternative Catalog Number: | ASB-OACA06838-100UL,ASB-OACA06838-50UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC, IP, WB |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Arginase-2, mitochondrial protein (1-354AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | arginase II,arginase, type II,arginase-2, mitochondrial,kidney arginase,kidney-type arginase,L-arginine amidinohydrolase,L-arginine ureahydrolase,nonhepatic arginase,non-hepatic arginase,type II arginase. |
| May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells (PubMed:27745970). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (By similarity). In fetal dendritic cells may play a role in promoting immune suppression and T cell TNF-alpha production during gestation (PubMed:28614294). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (PubMed:23832324). Since NOS is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase-2 plays a role in both male and female sexual arousal (PubMed:12859189). |
| Clonality: | Polyclonal |
| NCBI: | 384 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human lung cancer at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human prostate at dilution 1:100 |
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All lanes: Arginase-2, mitochondrial antibody at 5ug/ml Lane 1: mouse liver tissue Lane 2: |
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