TAP1 Antibody
Catalog Number:
ASB-OACA06996
- Images (3)
| Article Name: | TAP1 Antibody |
| Biozol Catalog Number: | ASB-OACA06996 |
| Supplier Catalog Number: | OACA06996 |
| Alternative Catalog Number: | ASB-OACA06996-100UL,ASB-OACA06996-50UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Antigen peptide transporter 1 protein (524-808AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | ABC transporter, MHC 1,ABC17,ABCB2,antigen peptide transporter 1,APT1,ATP-binding cassette sub-family B member 2,ATP-binding cassette, sub-family B (MDR/TAP), member 2,D6S114E,peptide supply factor 1,peptide transporter involved in antigen processing 1,peptide transporter PSF1,peptide transporter TAP1,PSF1,PSF-1,really interesting new gene 4 protein,RING4,TAP1*0102N,TAP1N,transporter 1 ATP-binding cassette sub-family B,transporter 1, ATP-binding cassette, sub-family B (MDR/TAP),transporter associated with antigen processing,transporter, ATP-binding cassette, major histocompatibility complex, 1. |
| Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. |
| Clonality: | Polyclonal |
| NCBI: | 6890 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human cervical cancer at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human pancreas at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human tonsil at dilution 1:100 |
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