Recombinant Human E3 ubiquitin-protein ligase CBL-C protein (245-474AA)
Conjugation:
Unconjugated
Alternative Names:
Cas-Br-M (murine) ecotropic retroviral transforming sequence c,Cas-Br-M (murine) ectropic retroviral transforming sequence c,Cbl proto-oncogene C, E3 ubiquitin protein ligase,Cbl proto-oncogene, E3 ubiquitin protein ligase C,CBL-3,CBL-SL,E3 ubiquitin-protein ligase CBL-C,RING finger protein 57,RING-type E3 ubiquitin transferase CBL-C,RNF57,SH3-binding protein CBL-3,SH3-binding protein CBL-C,signal transduction protein CBL-C.
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction, upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at Tyr-419. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation, CD2AP converts it from an inhibitor to a promoter of RET degradation, the function limits the potency of GDNF on neuronal survival.
