Recombinant Human Trimethylguanosine synthase protein (714-853AA)
Conjugation:
Unconjugated
Alternative Names:
cap-specific guanine-N2 methyltransferase,CLL-associated antigen KW-2,hepatocellular carcinoma-associated antigen 137,NCOA6IP,nuclear receptor coactivator 6-interacting protein,PIMT,PIPMT,PRIP-interacting protein with methyltransferase motif,trimethylguanosine synthase.
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.
