COPS4 Antibody
Catalog Number:
ASB-OACA07672
- Images (3)
| Article Name: | COPS4 Antibody |
| Biozol Catalog Number: | ASB-OACA07672 |
| Supplier Catalog Number: | OACA07672 |
| Alternative Catalog Number: | ASB-OACA07672-100UL,ASB-OACA07672-50UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC, WB |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human COP9 signalosome complex subunit 4 protein (1-310AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | COP9 constitutive photomorphogenic homolog subunit 4,COP9 constitutive photomorphogenic-like protein subunit 4,COP9 signalosome complex subunit 4,CSN4,JAB1-containing signalosome subunit 4,SGN4,signalosome subunit 4,testis tissue sperm-binding protein Li 42a. |
| Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
| Clonality: | Polyclonal |
| NCBI: | 51138 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human breast cancer at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human pancreas tissue at dilution 1:100 |
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Western blot All lanes: COPS4 antibody at 8ug/ml Lane 1: Hela whole cell lysate |
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