Recombinant Human Mothers against decapentaplegic homolog 3 protein (1-230AA)
Conjugation:
Unconjugated
Alternative Names:
hMAD-3,hSMAD3,HSPC193,HsT17436,JV15-2,LDS1C,LDS3,MAD homolog 3,mad homolog JV15-2,mad protein homolog,MAD, mothers against decapentaplegic homolog 3,mad3,MADH3,mothers against decapentaplegic homolog 3,mothers against DPP homolog 3,SMA- and MAD-related protein 3,SMAD family member 3,SMAD, mothers against DPP homolog 3.
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
