CCND3 Antibody
Catalog Number:
ASB-OACA07751
- Images (3)
| Article Name: | CCND3 Antibody |
| Biozol Catalog Number: | ASB-OACA07751 |
| Supplier Catalog Number: | OACA07751 |
| Alternative Catalog Number: | ASB-OACA07751-100UL,ASB-OACA07751-50UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IF, IHC, IP, WB |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human G1/S-specific cyclin-D3 protein (1-292AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | D3-type cyclin,G1/S-specific cyclin-D3. |
| Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. |
| Clonality: | Polyclonal |
| NCBI: | 896 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human lung cancer at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human tonsil tissue at dilution 1:100 |
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Western blot All lanes: CCND3 antibody at 6ug/ml Lane 1: NIH3T3 whole cell lysate |
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