PITRM1 Antibody
Catalog Number:
ASB-OACA08044
- Images (3)
| Article Name: | PITRM1 Antibody |
| Biozol Catalog Number: | ASB-OACA08044 |
| Supplier Catalog Number: | OACA08044 |
| Alternative Catalog Number: | ASB-OACA08044-100UL,ASB-OACA08044-50UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant Human Presequence protease, mitochondrial protein (758-1037AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | metalloprotease 1 (pitrilysin family),MP1,pitrilysin metalloproteinase 1,PreP,PreP peptidasome,presequence protease, mitochondrial,SCAR30. |
| Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing (PubMed:10360838, PubMed:16849325, PubMed:19196155, PubMed:24931469). Has an ATP-independent activity (PubMed:16849325). Specifically cleaves peptides in the range of 5 to 65 residues (PubMed:19196155). Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference (PubMed:10360838, PubMed:19196155, PubMed:24931469). Degrades the transit peptides of mitochondrial proteins after their cleavage (PubMed:19196155). Also degrades other unstructured peptides (PubMed:19196155). It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion (PubMed:16849325, PubMed:24931469). It is a highly efficient protease, at least toward amyloid-beta protein 40 (PubMed:24931469). Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently (PubMed:24931469). |
| Clonality: | Polyclonal |
| NCBI: | 10531 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human skeletal muscle tissue at dilution 1:100 |
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Western blot All lanes: PITRM1 antibody at 2.42ug/ml Lane 1: mouse placenta |
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