EYA3 Antibody
Catalog Number:
ASB-OACA08319
- Images (3)
| Article Name: | EYA3 Antibody |
| Biozol Catalog Number: | ASB-OACA08319 |
| Supplier Catalog Number: | OACA08319 |
| Alternative Catalog Number: | ASB-OACA08319-100UL,ASB-OACA08319-50UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC, WB |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Eyes absent homolog 3 protein (1-300AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | eyes absent 3,eyes absent homolog 3. |
| Tyrosine phosphatase that specifically dephosphorylates Tyr-142 of histone H2AX (H2AXY142ph). Tyr-142 phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. |
| Clonality: | Polyclonal |
| NCBI: | 2140 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human colon cancer at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human small intestine tissue at dilution 1:100 |
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Western blot All lanes: EYA3 antibody at 1.49ug/ml Lane 1A: Hela whole cell |
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