KPNA6 Antibody
Catalog Number:
ASB-OACA08335
- Images (3)
| Article Name: | KPNA6 Antibody |
| Biozol Catalog Number: | ASB-OACA08335 |
| Supplier Catalog Number: | OACA08335 |
| Alternative Catalog Number: | ASB-OACA08335-100UL,ASB-OACA08335-50UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC, WB |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Importin subunit alpha-7 protein (277-536AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | importin alpha 7 subunit,importin subunit alpha-7,importin-alpha-S2,IPOA7,karyopherin alpha 6 (importin alpha 7),Karyopherin subunit alpha-6. |
| Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| Clonality: | Polyclonal |
| NCBI: | 23633 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human adrenal gland tissue at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human prostate cancer at dilution 1:100 |
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Western blot All lanes: KPNA6 antibody at 4.25ug/ml Lane 1A: PC-3 whole ce |
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