Recombinant Human Eukaryotic translation initiation factor 3 subunit M protein (1-374AA)
Conjugation:
Unconjugated
Alternative Names:
B5,B5 receptor,dendritic cell protein,eukaryotic translation initiation factor 3 subunit M,fetal lung protein B5,GA17,hfl-B5,PCI domain containing 1 (herpesvirus entry mediator),PCI domain-containing protein 1,PCID1,TANGO7,transport and golgi organization 7 homolog.
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
