MYLIP Antibody
Catalog Number:
ASB-OACA08782
- Images (3)
| Article Name: | MYLIP Antibody |
| Biozol Catalog Number: | ASB-OACA08782 |
| Supplier Catalog Number: | OACA08782 |
| Alternative Catalog Number: | ASB-OACA08782-100UL,ASB-OACA08782-50UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC, WB |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human E3 ubiquitin-protein ligase MYLIP protein (266-445AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | band 4.1 superfamily member BZF1,cellular modulator of immune recognition (c-MIR),E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor,E3 ubiquitin-protein ligase MYLIP,IDOL,inducible degrader of the LDL-receptor,MIR,Myosin regulatory light chain interacting protein,RING-type E3 ubiquitin transferase MYLIP. |
| E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. |
| Clonality: | Polyclonal |
| NCBI: | 29116 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human heart tissue at dilution of 1:100 |
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Immunohistochemistry of paraffin-embedded human testis tissue at dilution of 1:100 |
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Western blot All lanes: MYLIP antibody at 4.06 ug/ml Lane 1: Mouse brain tissue |
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