PLK3 Antibody
Catalog Number:
ASB-OACA08911
- Images (3)
| Article Name: | PLK3 Antibody |
| Biozol Catalog Number: | ASB-OACA08911 |
| Supplier Catalog Number: | OACA08911 |
| Alternative Catalog Number: | ASB-OACA08911-100UL,ASB-OACA08911-50UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IHC, WB |
| Species Reactivity: | Human, Rat |
| Immunogen: | Recombinant Human Serine/threonine-protein kinase PLK3 protein (487-646AA) |
| Conjugation: | Unconjugated |
| Alternative Names: | CNK,cytokine-inducible serine/threonine-protein kinase,FGF-inducible kinase,FNK,PLK-3,Polo-like kinase 3,PRK,proliferation-related kinase,serine/threonine-protein kinase PLK3. |
| Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. |
| Clonality: | Polyclonal |
| NCBI: | 1263 |
| Form: | Liquid |
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Immunohistochemistry of paraffin-embedded human colon cancer at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human testis tissue at dilution 1:100 |
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Western blot All lanes: PLK3 antibody at 1.2ug/ml Lane 1: Rat heart tissue Lane |
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