Recombinant protein encompassing a sequence within the N-terminus region of human POLE. The exact sequence is proprietary.
Alternative Names:
FILS, POLE1, CRCS12, IMAGEI
This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature.
