TCF3 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human TCF3. The immunogen is located within amino acids 150 - 200 of TCF3.
Conjugation:
Unconjugated
Alternative Names:
AGM8,bHLHb21,class B basic helix-loop-helix protein 21,E2A,E2A-HLF fusion transcript protein,E47,helix-loop-helix protein HE47,Immunoglobulin enhancer-binding factor E12/E47,immunoglobulin transcription factor 1,ITF1,kappa-E2-binding factor,negative vitamin D response element-binding protein,NOL1-TCF3 fusion,p75,TCF-3,Transcription factor 3,transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47),transcription factor 3 variant 3,transcription factor E2-alpha,transcription factor ITF-1,VDIR,VDR interacting repressor,vitamin D receptor-interacting repressor.
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5-CANNTG-3. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.
