G protein-coupled receptors (GPCRs) is known to be involved in the pathogenesis of a variety of diseases, including cancer initiation and progression. Within this family, approximately 140 GPCRs have no known endogenous ligands and these orphan GPCRs remain poorly characterized. The orphan GPCR GPR19 was identified and cloned 2 decades ago. its expression to be elevated in breast cancers may play a potential role in breast cancer pathology.
