U1 small nuclear ribonucleoprotein C, U1 snRNP C, U1-C
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5 splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5 splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5 splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5 end of the U1 snRNA and the 5 splice-site region.
