Phospho-Retinoblastoma (S807) (4H3) Rabbit Monoclonal Antibody, Unconjugated

Catalog Number: EKL-AMRE05995
Article Name: Phospho-Retinoblastoma (S807) (4H3) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number: EKL-AMRE05995
Supplier Catalog Number: AMRe05995
Alternative Catalog Number: EKL-AMRE05995-50UL, EKL-AMRE05995-100UL, EKL-AMRE05995-200UL
Manufacturer: EnkiLife
Host: Rabbit
Category: Antikörper
Application: ICC, IHC, WB
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Alternative Names: P105-RB, PP105, PP110, RB-1, RB1, Retinoblastoma-associated protein,
Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral. Spontaneous regression (cure) occurs in some cases. Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle (PubMed:10499802). The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes (PubMed:10499802). Both physically blocks E2Fs transactivating domain and recruits chromatin- modifying enzymes that actively repress transcription (PubMed:10499802). Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase (PubMed:10499802). RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C (PubMed:15084261). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 Lys-20 trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1- dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex (By similarity).
Clonality: Monoclonal
Molecular Weight: 106kDa
NCBI: 5925
UniProt: P06400
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity: Affinity purification
Form: Liquid
Target: RB1
Application Dilute: WB 1:500-1:2000,IHC 1:200-1:500,ICC/IF 1:200-1:500



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