Phospho-SHIP (Y1020) (11Q1) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE06004
Product Overview
Article Name:
Phospho-SHIP (Y1020) (11Q1) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE06004
Supplier Catalog Number:
AMRe06004
Alternative Catalog Number:
EKL-AMRE06004-50UL, EKL-AMRE06004-100UL, EKL-AMRE06004-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
WB
Species Reactivity:
Human
Conjugation:
Unconjugated
Alternative Names:
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145, SH2 domain-containing inositol 5-phosphatase 1, SHIP-1, p150Ship, hp51CN, INPP5D, SHIP,
Product Description
SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and two NPXY Shc binding motifs in its carboxy terminus. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:8723348, PubMed: 10764818, PubMed: 8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed: 9108392, PubMed: 10764818, PubMed: 8769125). Acts as a negative regulator of B- cell antigen receptor signaling. Mediates signaling from the FC-gamma- RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed: 16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression.
Product Properties
Clonality:
Monoclonal
Molecular Weight:
133kDa
NCBI:
3635
UniProt:
Q92835
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
INPP5D
Application Notes
Application Dilute:
WB 1:1000-1:5000
