Phospho-Tau (T231) (10X15) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE06036
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| Article Name: | Phospho-Tau (T231) (10X15) Rabbit Monoclonal Antibody, Unconjugated |
| Biozol Catalog Number: | EKL-AMRE06036 |
| Supplier Catalog Number: | AMRe06036 |
| Alternative Catalog Number: | EKL-AMRE06036-50UL, EKL-AMRE06036-100UL, EKL-AMRE06036-200UL |
| Manufacturer: | EnkiLife |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | IF, IHC, IP, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Conjugation: | Unconjugated |
| Alternative Names: | MAPT, Microtubule-associated protein tau, MTBT1, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, |
| Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimers disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
| Clonality: | Monoclonal |
| Molecular Weight: | 79kDa |
| NCBI: | 4137 |
| UniProt: | P10636 |
| Buffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle. |
| Purity: | Affinity purification |
| Form: | Liquid |
| Target: | MAPT |
| Application Dilute: | WB 1:1000-1:5000,IHC 1:200-1:500,IP 1:20-1:50,IF-P 1:200-1:500 |
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