ABCD1 / ALD (12L9) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE06414
Product Overview
Article Name:
ABCD1 / ALD (12L9) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE06414
Supplier Catalog Number:
AMRe06414
Alternative Catalog Number:
EKL-AMRE06414-50UL, EKL-AMRE06414-100UL, EKL-AMRE06414-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
FC, ICC, WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
Unconjugated
Alternative Names:
ABC42, Abcd1, ALD, Aldgh, ALDP, AMN,
Product Description
Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)- CoA from the cytosol to the peroxisome lumen (PubMed:11248239, PubMed: 15682271, PubMed: 16946495, PubMed: 18757502, PubMed: 21145416, PubMed: 23671276, PubMed: 29397936, PubMed: 33500543). Coupled to the ATP- dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP- dependent transport into peroxisomes, the ACOT activity is essential during this transport process (PubMed: 33500543, PubMed: 29397936). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed: 23671276, PubMed: 21145416). Involved in several processes, namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance. Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (By similarity).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
83kDa
NCBI:
215
UniProt:
P33897
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
ABCD1
Application Notes
Application Dilute:
WB 1:1000-1:2000,ICC/IF 1:100-1:200,FC 1:20-1:50
