active Caspase-3 (2M18) Rabbit Monoclonal Antibody, Unconjugated

Catalog Number: EKL-AMRE06554
Article Name: active Caspase-3 (2M18) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number: EKL-AMRE06554
Supplier Catalog Number: AMRe06554
Alternative Catalog Number: EKL-AMRE06554-50UL, EKL-AMRE06554-100UL, EKL-AMRE06554-200UL
Manufacturer: EnkiLife
Host: Rabbit
Category: Antikörper
Application: ICC, IHC, WB
Species Reactivity: Human
Conjugation: Unconjugated
Alternative Names: Apopain precursor, Cysteine protease CPP32, ICE3, CASP-3, CPP32, Caspase-3, SCA-1,
Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Involved in the activation cascade of caspases responsible for apoptosis execution (PubMed:7596430). At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216- Asp-|-Gly-217 bond (PubMed:7774019). Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix- loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (PubMed:7596430). Involved in the cleavage of huntingtin (PubMed:8696339). Triggers cell adhesion in sympathetic neurons through RET cleavage (PubMed:21357690). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress (PubMed:23152800). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (PubMed:23845944, PubMed:33725486).
Clonality: Monoclonal
Molecular Weight: 32kDa
NCBI: 836
UniProt: P42574
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity: Affinity purification
Form: Liquid
Target: CASP3
Application Dilute: WB 1:1000-1:2000,IHC 1:100-1:200,ICC/IF 1:50-1:200



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