AIF (11G15) Rabbit Monoclonal Antibody, Unconjugated

Catalog Number: EKL-AMRE06698
Article Name: AIF (11G15) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number: EKL-AMRE06698
Supplier Catalog Number: AMRe06698
Alternative Catalog Number: EKL-AMRE06698-50UL, EKL-AMRE06698-100UL, EKL-AMRE06698-200UL
Manufacturer: EnkiLife
Host: Rabbit
Category: Antikörper
Application: FC, ICC, IHC, IP, WB
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Alternative Names: AIFM1, AIF, PDCD8, COXPD6,
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. Functions both as NADH oxidoreductase and as regulator of apoptosis (PubMed:20362274, PubMed:23217327, PubMed:17094969). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. The soluble form (AIFsol) found in the nucleus induces parthanatos i.e. caspase-independent fragmentation of chromosomal DNA (By similarity). Binds to DNA in a sequence-independent manner (PubMed:27178839). Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates caspase-7 to amplify apoptosis (PubMed:17094969). Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells (PubMed:19418225). In contrast, participates in normal mitochondrial metabolism. Plays an important role in the regulation of respiratory chain biogenesis by interacting with CHCHD4 and controlling CHCHD4 mitochondrial import (PubMed:26004228).
Clonality: Monoclonal
Molecular Weight: 67kDa
NCBI: 9131
UniProt: O95831
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity: Affinity purification
Form: Liquid
Target: AIFM1
Application Dilute: WB 1:500-1:2000,IHC 1:50-1:200,ICC/IF 1:100-1:200,FC 1:20-1:50,IP 1:20-1:50



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