ANP (19C4) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE06936
Product Overview
Article Name:
ANP (19C4) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE06936
Supplier Catalog Number:
AMRe06936
Alternative Catalog Number:
EKL-AMRE06936-50UL, EKL-AMRE06936-100UL, EKL-AMRE06936-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
IF, IHC, IP, WB
Species Reactivity:
Human, Rat
Conjugation:
Unconjugated
Alternative Names:
ANF, ANP, PND, ATFB6, CDD-ANF, NPPA, Natriuretic peptides A, LANP, VSDL,
Product Description
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. [Atrial natriuretic peptide]: Hormone that plays a key role in mediating cardio-renal homeostasis, and is involved in vascular remodeling and regulating energy metabolism (PubMed:8653797, PubMed: 7595132, PubMed: 2825692, PubMed: 7720651, PubMed: 8087923, PubMed: 2532366, PubMed: 22307324, PubMed: 18835931, PubMed: 21672517, PubMed: 15741263, PubMed: 16875975). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins, such as PRKG1, that drive various biological responses (PubMed: 25401746, PubMed: 9893117, PubMed: 1672777, PubMed: 1660465, PubMed: 2162527, PubMed: 2825692, PubMed: 7720651, PubMed: 22307324, PubMed: 8384600, PubMed: 21098034). Regulates vasodilation, natriuresis, diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure, controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance (PubMed: 8653797, PubMed: 7595132, PubMed: 2825692, PubMed: 7720651, PubMed: 2532366, PubMed: 8087923). Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts (PubMed: 16875975). Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus, and thus prevents pregnancy-induced hypertension (By similarity). In adipose tissue, acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeostasis (PubMed: 22307324, PubMed: 18835931, PubMed: 21672517, PubMed:
Product Properties
Clonality:
Monoclonal
Molecular Weight:
16kDa
NCBI:
4878
UniProt:
P01160
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
NPPA
Application Notes
Application Dilute:
WB 1:500-1:2000,IHC 1:500-1:2000,IP 1:20-1:50,IF-P 1:500-1:2000
