ASPP2 (7U15) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE07230
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| Article Name: | ASPP2 (7U15) Rabbit Monoclonal Antibody, Unconjugated |
| Biozol Catalog Number: | EKL-AMRE07230 |
| Supplier Catalog Number: | AMRe07230 |
| Alternative Catalog Number: | EKL-AMRE07230-50UL, EKL-AMRE07230-100UL, EKL-AMRE07230-200UL |
| Manufacturer: | EnkiLife |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | IHC, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Conjugation: | Unconjugated |
| Alternative Names: | 53BP2, ASPP2, p53BP2, PPP1R13A, Tp53bp2, |
| Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. |
| Clonality: | Monoclonal |
| Molecular Weight: | 126kDa |
| NCBI: | 7159 |
| UniProt: | Q13625 |
| Buffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle. |
| Purity: | Affinity purification |
| Form: | Liquid |
| Target: | TP53BP2 |
| Application Dilute: | WB 1:2000-1:20000,IHC 1:200-1:1000 |
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