ATG9A (7Z14) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE07301
Product Overview
Article Name:
ATG9A (7Z14) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE07301
Supplier Catalog Number:
AMRe07301
Alternative Catalog Number:
EKL-AMRE07301-50UL, EKL-AMRE07301-100UL, EKL-AMRE07301-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
FC, ICC, IHC, IP, WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
Unconjugated
Alternative Names:
ATG9A, APG9-like 1, Autophagy 9-like 1 protein, Autophagy-related protein 9A, MGD3208, MATG9, APG9 autophagy 9-like 1, APG9L1, Autophagy related 9A,
Product Description
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:22456507, PubMed: 27510922, PubMed: 29437695, PubMed: 32513819, PubMed: 33468622, PubMed: 33850023, PubMed: 32610138, PubMed: 33106659). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (PubMed: 16940348, PubMed: 22456507, PubMed: 33106659). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (PubMed: 33106659). Also required to supply phosphatidylinositol 4- phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (PubMed: 30917996). In addition to autophagy, also plays a role in necrotic cell death (By similarity).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
94kDa
NCBI:
79065
UniProt:
Q7Z3C6
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
ATG9A
Application Notes
Application Dilute:
WB 1:500-1:2000,IHC 1:50-1:100,ICC/IF 1:50-1:100,FC 1:20-1:50,IP 1:10-1:100
