Calcineurin A (15E13) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE07849
Product Overview
Article Name:
Calcineurin A (15E13) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE07849
Supplier Catalog Number:
AMRe07849
Alternative Catalog Number:
EKL-AMRE07849-50UL, EKL-AMRE07849-100UL, EKL-AMRE07849-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
FC, IP, WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
Unconjugated
Alternative Names:
Calcineurin A1, CalcineurinA, CALN, CALNA 1, CALNA, CALNA1, CAM PRP, CNA alpha, CCN1,
Product Description
Calcineurin, also known as protein phosphatase 2B (PP2B), is a calmodulin-dependent, calcium-activated, serine/threonine protein phosphatase composed of a catalytic subunit (calcineurin A) and a tightly bound regulatory subunit (calcineurin B). Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1. Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed: 18838687, PubMed: 19154138, PubMed: 23468591). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed: 17498738, PubMed: 17502104, PubMed: 23468591, PubMed: 27974827, PubMed: 22343722). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed: 15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed: 18838687). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed: 19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed: 26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed: 19154138). Dephosphorylates DARPP32 (PubMed: 19154138). May dephosphorylate CRTC2 at Ser-171 resulting in CRTC2 dissociation from 14-3-3 proteins (PubMed: 30611118). Dephosphorylates transcription factor TFEB at Ser-211 following Coxsackievirus B3 infection, promoting nuclear translocation (PubMed: 33691586).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
59kDa
NCBI:
5530
UniProt:
Q08209
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
PPP3CA
Application Notes
Application Dilute:
WB 1:1000-1:2000,FC 1:20-1:50,IP 1:20-1:50
