CARD11 (6T8) Rabbit Monoclonal Antibody, Unconjugated

Catalog Number: EKL-AMRE07927
Article Name: CARD11 (6T8) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number: EKL-AMRE07927
Supplier Catalog Number: AMRe07927
Alternative Catalog Number: EKL-AMRE07927-50UL, EKL-AMRE07927-100UL, EKL-AMRE07927-200UL
Manufacturer: EnkiLife
Host: Rabbit
Category: Antikörper
Application: WB
Species Reactivity: Human, Mouse
Conjugation: Unconjugated
Alternative Names: CARD11, CARMA1, Carma 1, BIMP3,
Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T- cell receptor (TCR) and B-cell receptor (BCR) engagement (PubMed:11278692, PubMed:11356195, PubMed:12356734). Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways (PubMed:11356195). Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation (PubMed:24074955). Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP (PubMed:27777308). Stimulates the phosphorylation of BCL10 (PubMed:11356195). Also activates the TORC1 signaling pathway (PubMed:28628108).
Clonality: Monoclonal
Molecular Weight: 133kDa
NCBI: 84433
UniProt: Q9BXL7
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity: Affinity purification
Form: Liquid
Target: CARD11
Application Dilute: WB 1:1000-1:5000



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