Caspase-14 (7P17) Rabbit Monoclonal Antibody, Unconjugated

Catalog Number: EKL-AMRE07965
Article Name: Caspase-14 (7P17) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number: EKL-AMRE07965
Supplier Catalog Number: AMRe07965
Alternative Catalog Number: EKL-AMRE07965-50UL, EKL-AMRE07965-100UL, EKL-AMRE07965-200UL
Manufacturer: EnkiLife
Host: Rabbit
Category: Antikörper
Application: FC, ICC, IHC, IP, WB
Species Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Alternative Names: CASP14, Caspase-14, Caspase 14, MICE, CASP-14,
Caspases are a family of cysteine proteases that play an essential role in carrying out apoptosis. Caspase-14, also named MICE, is a unique member of the caspase family with restricted expression, it is found in embryonic tissues and adult skin. Caspase-14 is weakly processed into p18 and p11 subunits by caspase-8. May also be responsible for proteolytic processing of filaggrin during terminal differentiation of keratinocytes. Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
Clonality: Monoclonal
Molecular Weight: 28kDa
NCBI: 23581
UniProt: P31944
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity: Affinity purification
Form: Liquid
Target: CASP14
Application Dilute: WB 1:1000-1:5000,IHC 1:100-1:200,ICC/IF 1:100-1:200,FC 1:10-1:100,IP 1:10-1:100



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