CD35 (4U8) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE08375
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| Article Name: | CD35 (4U8) Rabbit Monoclonal Antibody, Unconjugated |
| Biozol Catalog Number: | EKL-AMRE08375 |
| Supplier Catalog Number: | AMRe08375 |
| Alternative Catalog Number: | EKL-AMRE08375-50UL, EKL-AMRE08375-100UL, EKL-AMRE08375-200UL |
| Manufacturer: | EnkiLife |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | IHC, WB |
| Species Reactivity: | Human |
| Conjugation: | Unconjugated |
| Alternative Names: | C3 binding protein, C3b/C4b receptor, C3BR, C4BR, CD35, CR1, KN, |
| Mediates cellular binding of particles and immune complexes that have activated complement. Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation (PubMed:2963069). Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d (PubMed:2972794, PubMed:8175757). Plays also a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells (PubMed:25742728). |
| Clonality: | Monoclonal |
| Molecular Weight: | 224kDa |
| NCBI: | 1378 |
| UniProt: | P17927 |
| Buffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle. |
| Purity: | Affinity purification |
| Form: | Liquid |
| Target: | CR1 |
| Application Dilute: | WB 1:1000-1:5000,IHC 1:200-1:500 |
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