MALT1 (7A3) Rabbit Monoclonal Antibody, Unconjugated

Catalog Number: EKL-AMRE13606
Article Name: MALT1 (7A3) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number: EKL-AMRE13606
Supplier Catalog Number: AMRe13606
Alternative Catalog Number: EKL-AMRE13606-50UL, EKL-AMRE13606-100UL, EKL-AMRE13606-200UL
Manufacturer: EnkiLife
Host: Rabbit
Category: Antikörper
Application: WB
Species Reactivity: Human
Conjugation: Unconjugated
Alternative Names: Malt1, MLT1, Mucosa associated lymphoid tissue lymphoma translocation gene 1, Paracaspase,
Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475).
Clonality: Monoclonal
Molecular Weight: 92kDa
NCBI: 10892
UniProt: Q9UDY8
Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity: Affinity purification
Form: Liquid
Target: MALT1
Application Dilute: WB 1:1000-1:5000



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