MyD88 (5Y8) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE14273
Product Overview
Article Name:
MyD88 (5Y8) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE14273
Supplier Catalog Number:
AMRe14273
Alternative Catalog Number:
EKL-AMRE14273-50UL, EKL-AMRE14273-100UL, EKL-AMRE14273-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
IP, WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
Unconjugated
Alternative Names:
Myeloid differentiation primary response protein MyD88, MYD88,
Product Description
Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed: 18292575, PubMed: 33718825). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed: 15361868, PubMed: 24316379, PubMed: 19506249). Increases IL-8 transcription (PubMed: 9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation (PubMed: 33718825). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
33kDa
NCBI:
4615
UniProt:
Q99836
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
MYD88
Application Notes
Application Dilute:
WB 1:500-1:2000,IP 1:20-1:50
