p62/SQSTM1 (12N5) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE15658
Product Overview
Article Name:
p62/SQSTM1 (12N5) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE15658
Supplier Catalog Number:
AMRe15658
Alternative Catalog Number:
EKL-AMRE15658-50UL, EKL-AMRE15658-100UL, EKL-AMRE15658-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
FC, ICC, IHC, IP, WB
Species Reactivity:
Human, Mouse, Rat
Conjugation:
Unconjugated
Alternative Names:
OSIL, Oxidative stress induced like, p60, p62, p62B, Paget disease of bone 3,PDB 3, PDB3,
Product Description
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed: 20168092, PubMed: 24128730, PubMed: 28404643, PubMed: 22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed: 24128730, PubMed: 20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed: 27368102). Promotes relocalization of Lys-63-linked ubiquitinated STING1 to autophagosomes (PubMed: 29496741). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed: 20452972, PubMed: 28380357).
Product Properties
Clonality:
Monoclonal
Molecular Weight:
48kDa
NCBI:
8878
UniProt:
Q13501
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
SQSTM1
Application Notes
Application Dilute:
WB 1:500-1:2000,IHC 1:20-1:100,ICC/IF 1:20-1:50,FC 1:50-1:100,IP 1:20-1:50
