TMEM173 (3U7) Rabbit Monoclonal Antibody, Unconjugated
Catalog Number:
EKL-AMRE19051
Product Overview
Article Name:
TMEM173 (3U7) Rabbit Monoclonal Antibody, Unconjugated
Biozol Catalog Number:
EKL-AMRE19051
Supplier Catalog Number:
AMRe19051
Alternative Catalog Number:
EKL-AMRE19051-50UL, EKL-AMRE19051-100UL, EKL-AMRE19051-200UL
Manufacturer:
EnkiLife
Host:
Rabbit
Category:
Antikörper
Application:
FC, ICC, IHC, IP, WB
Species Reactivity:
Human
Conjugation:
Unconjugated
Alternative Names:
ERIS, hMITA, hSTING, MITA, MPYS, NET23, STING, Tmem173, STING1,Stimulator of interferon genes protein,
Product Description
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed: 18818105, PubMed: 19433799, PubMed: 19776740, PubMed: 23027953, PubMed: 23910378, PubMed: 23747010, PubMed: 30842659). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (PubMed: 26300263). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c- di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol (PubMed: 21947006, PubMed: 23258412, PubMed: 23707065, PubMed: 23722158, PubMed: 26229117, PubMed: 23910378, PubMed: 23747010, PubMed: 30842659). Upon binding of c-di-GMP or cGAMP, STING1 oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state (PubMed: 22394562, PubMed: 25636800, PubMed: 30842653). In addition to promote the production of type I interferons, plays a direct role in autophagy (PubMed: 30568238, PubMed: 30842662). Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (PubMed: 30842662). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome (PubMed: 30842662). The autophagy- and interferon- inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation (PubMed: 30568238, PubMed: 308
Product Properties
Clonality:
Monoclonal
Molecular Weight:
42kDa
NCBI:
340061
UniProt:
Q86WV6
Buffer:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle.
Purity:
Affinity purification
Form:
Liquid
Target:
STING
Application Notes
Application Dilute:
WB 1:500-1:2000,IHC 1:500-1:2000,ICC/IF 1:100-1:200,FC 1:200-1:500,IP 1:20-1:50
