Cell localization:Cytoplasm.This gene encodes a component of a signaling pathway that regµLates cell growth in response to nutrient and insµLin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regµLates the downstream effector ribosomal protein S6 kinase, and negatively regµLates the mTOR kinase. MµLtiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
