PDGFRB,PDGFR,PDGFR1,Platelet-derived growth factor receptor beta,PDGF-R-beta,PDGFR-beta,Beta platelet-derived growth factor receptor,Beta-type platelet-derived growth factor receptor,CD140 antigen-like family member B,Platelet-deri
Cell localization:Membrane.This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granµLocyte-macrophage colony-stimµLating factor and macrophage-colony stimµLating factor receptor, all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, resµLts in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, JµL 2008],
