CD63,MLA1,TSPAN30,CD63 antigen,GranmuLophysin,Lysosomal-associated membrane protein 3,LAMP-3,Melanoma-associated antigen ME491,OMA81H,OcmuLar melanoma-associated antigen,Tetraspanin-30,Tspan-30,CD63
Cell localization:Membrane.The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regµLation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing resµLts in mµLtiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012],
