Cell localization:Cytoplasm, Nucleus.The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals inThe body.The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmfµL superoxide radicals to molecµLar oxygen and hydrogen peroxide.The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, JµL 2008],
