Cell localization:Cytoplasm.This gene encodes a calmodµLin- and actin-binding protein that plays an essential role inThe regµLation of smooth muscle and nonmuscle contraction.The conserved domain of this protein possessesThe binding activities to Ca(2+)-calmodµLin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor ofThe actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene resµLts in mµLtiple transcript variants encoding distinct isoforms. [provided by RefSeq, JµL 2008],
