POU5F1,OCT3,OCT4,OTF3,POU domain, class 5, transcription factor 1,Octamer-binding protein 3,Oct-3,Octamer-binding protein 4,Oct-4,Octamer-binding transcription factor 3,OTF-3
Cell localization:Nucleus.This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adµLt tissues is associated with tumorigenesis. This gene can participate in a translocation withThe Ewings sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, resµLts in mµLtiple isoforms. One ofThe AUG start codons is polymorphic in human popµLations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013],
