Cell localization:Cytoplasm.The protein encoded by this gene isThe tropomyosin-binding subunit ofThe troponin complex, which is located onThe thin filament of striated muscles and regµLates muscle contraction in response to alterations in intracellµLar calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that resµLts in many tissue-specific isoforms, however,The fµLl-length nature of some of these variants has not yet been determined. [provided by RefSeq, JµL 2008],
