Cell localization:Secreted.This gene encodes a secreted extracellµLar matrix protein that functions in tissue development and regeneration, including wound healing, and ventricµLar remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing resµLts in mµLtiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015],
