PRKACA,PKACA,cAMP-dependent protein kinase catalytic subunit alpha,PKA C-alpha
Cell localization:Cytoplasm, Membrane.This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regµLatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regµLatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regµLatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellµLar processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushings syndrome. Altern
