Cell localization:Cytoplasm.This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as mµLtiple DNA repair processes. Alternative splicing resµLts in mµLtiple transcript variants. [provided by RefSeq, Dec 2015]
