Cell localization:Cytoplasm, Nucleus.This gene encodes a member of the interferon regµLatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding mµLtiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],
